These findings help to understand the differences in pathophysiology in patients developing major versus no/minor bowel complaints after TME for rectal cancer. CONCLUSIONS AND INFERENCES: The occurrence of more cyclic short antegrade motor patterns and less HAPC's (from the proximal to the mid-colon) is more prevalent in patients with major LARS. High amplitude propagating contractions (HAPC's) that started in the proximal colon and ended in the mid-section of the colon occurred significantly less in patients with major LARS compared with patients with no/minor LARS (p = 0.015). Cyclic short antegrade motor patterns did occur more in patients with major LARS (total: p = 0.022 post-bisacodyl: p = 0.004) and were strongly correlated to LARS-scores after administering bisacodyl (p < / 0.001). KEY RESULTS: Data were analyzed in 18 patients (9 no/minor LARS, 9 major LARS). Colonic motor patterns were compared, and the relationship of these patterns with the LARS-scores was investigated. Patients were divided into two groups: patients with major LARS and no/minor LARS, according to the LARS-score. METHODS: High-resolution colon manometry was performed in patients, 12-24 months after restoration of transit. The exact pathophysiology of this syndrome still remains largely unknown, and the impact of radical surgery on colonic motility has only been scarcely investigated. CONCLUSIONS: PFMT for bowel symptoms after TME resulted in lower proportions and faster recovery of bowel symptoms up to six months after surgery/stoma closure, justifying PFMT as an early, first-line treatment option for bowel symptoms after RC.īACKGROUND: A total mesorectal excision for rectal cancer-although nerve- and sphincter-sparing-can give rise to significant bowel symptoms, commonly referred to as low anterior resection syndrome (LARS). No significant differences were found for NRS- /QoL-scores. Following secondary outcomes were significantly lower at four months: LARS-scores (continuous, P=0.0496), COREFO-scores (P=0.0369) and frequency of bowel movements (P=0.0277), solid stool leakage (day, P=0.0241 night, P=0.0496) and the number of clusters (P=0.0369), derived from the stool diary. RESULTS: The proportion of participants with an improvement in LARS-category was statistically higher after PFMT compared to controls at four (38.3% vs. Secondary outcomes were: continuous LARS-scores, COREFO-scores, NRS-scores, stool diary items and SF-12 scores all assessed at 1, 4, 6 and 12 months. Primary endpoint was the proportion of participants with an improvement in LARS category at four months.
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METHODS: A multicenter single-blind prospective randomized controlled trial (RCT) comparing PFMT (intervention n=50) versus no PFMT (control n=54) one month following TME/stoma closure was performed. The objective was to investigate PFMT-effectiveness on LARS in patients after TME for RC. Although pelvic floor muscle training (PFMT) is recommended in non-cancer populations for treating bowel symptoms, this has been scarcely investigated in RC-patients. SUMMARY BACKGROUND DATA AND OBJECTIVE: Total mesorectal excision (TME) for rectal cancer (RC) often results in significant bowel symptoms, commonly known as Low Anterior Resection Syndrome (LARS). Towards a better understanding of pain after surgery for breast cancer: a biopsychosocial perspective ( - ).Pain science education after breast cancer surgery ( - ).Lymphoedema and nocturia/ nocturnal polyuria after pelvic lymph node dissection (LND) for urogenital cancer ( - ).Improving health-related quality of life of head and neck cancer patients via a dedicated comprehensive supervised exercise program (CSEP) ( - ).
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